2.3.4 Search information by TF

Users can submit a TF of interest search to access scATAC-seq data and fine-mapping result data associated with this TF.

../../_images/tf1.png

The results are divided into three parts, as follows:

  1. TF details and number of traits enriched by TFs under different reference genome backgrounds.

img/search/tf/tf_overview.png

  1. It shows the traits or diseases enriched in this TF by HOMER.

../../_images/tf_trait.png

Click the ‘View’ button to see the details of a trait or disease associated with this TF.

../../_images/tf_trait_view.png

Click the button on the link to get the result of HOMER motif enrichment running. (The first column in the table.)

../../_images/tf_trait_link.png

Note

Due to the fact that there may be too few causal variants in some trait or disease data, motif enrichment may not occur, so a very small portion may not have linking results.

  1. Displays the samples containing TFs that are different from cell types in single cell samples.

../../_images/tf_sample.png

Note

The scATAC-seq sample data of associated TFs is the most relaxed standard, without any strict threshold. Specific information needs to be accessed by clicking on the Sample ID to enter the “Detail” page.